Guitar Hero III song to cause instant arthritis, carpal tunnel, epilepsy, death
Exhibit A: Through the Fire and Flames, as made famous by Dragonforce.
I thought I was hot stuff when I pulled a 92% on Miserlou on Expert. But this song, I fear, would make Dick Dale's brain shoot out of his ears. I wonder if you get bonus points if you can play it whilst holding a massive broadsword?

